Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder; Melissa M. Wu; Nisan Ozana; Davide Tamborini; Maria Angela Franceschini; Stefan A. Carp

doi:10.1117/12.2577787

5 March 2021 Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow

Dibbyan Mazumder, Melissa M. Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, Stefan A. Carp

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Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 116410F (2021) https://doi.org/10.1117/12.2577787
Event: SPIE BiOS, 2021, Online Only

Abstract

The ability of diffuse correlation spectroscopy (DCS) to measure tissue perfusion paves the way for monitoring cerebral blood flow (CBF) non-invasively. However, during measurements on human forehead, the measured blood flow index (BFi) is susceptible to contamination due to the blood flow in extracerebral tissue. Time domain DCS addresses this problem by selecting photons based on their travel time to obtain BFi at various depths. We have determined the gate start time(s) and width(s) that can lead to optimal sensitivity of BFi to CBF during actual measurements on human subjects through simulations. The simulated parameters were compared with measurement data.

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Dibbyan Mazumder, Melissa M. Wu, Nisan Ozana, Davide Tamborini, Maria Angela Franceschini, and Stefan A. Carp "Simulation and experimental verification of optimal time domain diffuse correlation spectroscopy (TD-DCS) parameters for measuring brain blood flow", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 116410F (5 March 2021); https://doi.org/10.1117/12.2577787

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KEYWORDS

Monte Carlo methods

Blood circulation

Spectroscopy

Brain

Tissue optics

Geometrical optics

Tissues

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