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7 March 2021 Cooled infrared optoacoustic spectroscopy (CIROAS) for accurate sensing based on water muting
Jaya Prakash, Mir Mehdi Seyedebrahimi, Ara Ghazaryan, Jaber Malekzadeh-Najafabadi, Vipul Gujrati, Vasilis Ntziachristos
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Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422B (2021) https://doi.org/10.1117/12.2582335
Event: SPIE BiOS, 2021, Online Only
Abstract
The detection sensitivity of optoacoustic spectroscopy at the short-wavelength infrared (SWIR) region is reduced by water absorption in aqueous solutions. Our work reports marked improvements in the sensitivity of optoacoustic spectroscopic measurements of proteins, lipids, and glucose when performed at 4 °C, compared to conventional optoacoustic or IR spectroscopy. Studying the effect of water temperature on optoacoustic signals revealed a polarity change at temperatures below 4 °C (muting temperature). The dependence of the optoacoustic signal and the muting temperature on sample concentration were further investigated, demonstrating that changes in these dependencies enable accurate quantification of the solute concentration.
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Jaya Prakash, Mir Mehdi Seyedebrahimi, Ara Ghazaryan, Jaber Malekzadeh-Najafabadi, Vipul Gujrati, and Vasilis Ntziachristos "Cooled infrared optoacoustic spectroscopy (CIROAS) for accurate sensing based on water muting", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422B (7 March 2021); https://doi.org/10.1117/12.2582335
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KEYWORDS
Infrared spectroscopy
Optoacoustics
Spectroscopy
Infrared radiation
Infrared sensors
Absorption
Molecules
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