Nano-pulsed laser therapy of abnormal hippocampal neurogenesis after traumatic brain injury

Emanuele Mocciaro; Rinat O. Esenaliev; Stacey Sell; Irene Petrov; Yuriy Petrov; Elizabeth Bishop; Kathia Johnson; Donald Prough; Maria-Adelaide Micci

doi:10.1117/12.2584191

9 March 2021 Nano-pulsed laser therapy of abnormal hippocampal neurogenesis after traumatic brain injury

Emanuele Mocciaro, Rinat O. Esenaliev, Stacey Sell, Irene Petrov, Yuriy Petrov, Elizabeth Bishop, Kathia Johnson, Donald Prough, Maria-Adelaide Micci

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422J (2021) https://doi.org/10.1117/12.2584191
Event: SPIE BiOS, 2021, Online Only

Abstract

Recently we proposed to use optoacoustic therapy/Nano-Pulse Laser Therapy-NPLT and tested it in rats with traumatic brain injury (TBI). In this study we used an optoacoustic system operating at 808 nm and demonstrated that NPLT prevented TBI-induced upregulation of specific microRNAs (miRNAs) in NSC and significantly decreased TBI-induced impaired maturation and abnormal migration of neural progenitors. Moreover, NPLT-treated injured rats performed significantly better in hippocampus-dependent cognitive tests than did sham rats. Our results strongly suggest that NPLT has the potential to be an effective tool for the treatment of TBI-induced cognitive dysfunction and dysregulation of neurogenesis.

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Emanuele Mocciaro, Rinat O. Esenaliev, Stacey Sell, Irene Petrov, Yuriy Petrov, Elizabeth Bishop, Kathia Johnson, Donald Prough, and Maria-Adelaide Micci "Nano-pulsed laser therapy of abnormal hippocampal neurogenesis after traumatic brain injury", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422J (9 March 2021); https://doi.org/10.1117/12.2584191

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