Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography

Isaac C. Donis; James P. McLean; Christine P. Hendon

doi:10.1117/12.2577426

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5 March 2021 Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography

Isaac C. Donis, James P. McLean, Christine P. Hendon

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Proceedings Volume 11649, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII; 1164913 (2021) https://doi.org/10.1117/12.2577426
Event: SPIE BiOS, 2021, Online Only

Abstract

We propose a method to construct a three-dimensional volumetric representation of uterine tissue through the full thickness of the uterine wall using Optical Coherence Tomography (OCT). Uterine tissue blocks from human donors were cut into ~4 mm thin slices and imaged on both sides using a commercial OCT system with 2 mm imaging depth. Attenuation compensation, rigid registration, image blending techniques were used to combine the OCT mosaic volumes from each side of the tissue into a single volume. Initial results suggest this method yields a representative 3D view of uterine collagen fiber architecture through the full tissue thickness.

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Isaac C. Donis, James P. McLean, and Christine P. Hendon "Visualizing the full depth of the human uterine wall through three-dimensional mosaic Optical Coherence Tomography", Proc. SPIE 11649, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVIII, 1164913 (5 March 2021); https://doi.org/10.1117/12.2577426

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