Quantitative label-free characterisation and discrimination of osteoarthritis and rheumatoid arthritis based on hyperspectral autofluorescence features

Saabah B. Mahbub; Jared Campbell; Florence J. Lees; Anna Guller; Martin E. Gosnell; Ayad Anwer; Tania Crotti; Mihir D. Wechalekar; Mark R. Hutchinson; Ewa Goldys

doi:10.1117/12.2578486

5 March 2021 Quantitative label-free characterisation and discrimination of osteoarthritis and rheumatoid arthritis based on hyperspectral autofluorescence features

Saabah B. Mahbub, Jared Campbell, Florence J. Lees, Anna Guller, Martin E. Gosnell, Ayad Anwer, Tania Crotti, Mihir D. Wechalekar, Mark R. Hutchinson, Ewa Goldys

Author Affiliations +

Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116551I (2021) https://doi.org/10.1117/12.2578486
Event: SPIE BiOS, 2021, Online Only

Abstract

Pain is currently assessed using subjective measurements, often not aligning with clinical symptoms. Therefore, objective pain level assessments, using minimally-invasive and molecular methods, are needed to assess disease activity and response to treatment in osteoarthritis and rheumatoid arthritis. We report sophisticated quantitative biochemical “signatures” from the label-free hyperspectral imaging (HSI) of cartilage tissue for the characterization of molecular composition, structure and functional status. Further study on sinuvium tissue provides evidence that HSI could be used as a novel technique to delineate disease state. Additionally, HSI could be used to objectively separate individuals based on pain severity providing molecular correlates of pain.

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Saabah B. Mahbub, Jared Campbell, Florence J. Lees, Anna Guller, Martin E. Gosnell, Ayad Anwer, Tania Crotti, Mihir D. Wechalekar, Mark R. Hutchinson, and Ewa Goldys "Quantitative label-free characterisation and discrimination of osteoarthritis and rheumatoid arthritis based on hyperspectral autofluorescence features", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116551I (5 March 2021); https://doi.org/10.1117/12.2578486

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