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5 March 2021 Nonlinear optics improves mid-infrared vibrational imaging
Dave Knez, Richard C. Prince, Adam M. Hanninen, Dmitry Fishman, Eric O. Potma
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Proceedings Volume 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021; 116561J (2021) https://doi.org/10.1117/12.2579115
Event: SPIE BiOS, 2021, Online Only
Abstract
Vibrational microscopy based on the mid-infrared (MIR) absorption of molecular modes is a proven strategy for label-free imaging. Yet, as a tool for cellular imaging, MIR vibrational imaging suffers from several shortcomings., among which the low spatial resolution and the unavailability of affordable imaging cameras with high pixel densities. In this presentation, we will discuss how nonlinear optical (NLO) interactions can be employed to improve MIR imaging considerably. First, we introduce a new NLO method for capturing MIR images on a regular Si-based camera. Second, we highlight how NLO interactions can be used to improve the resolution in MIR microscopy.
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Dave Knez, Richard C. Prince, Adam M. Hanninen, Dmitry Fishman, and Eric O. Potma "Nonlinear optics improves mid-infrared vibrational imaging", Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 116561J (5 March 2021); https://doi.org/10.1117/12.2579115
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KEYWORDS
Nonlinear optics
Mid-IR
Cameras
Microscopy
Chemical analysis
Image resolution
Imaging spectroscopy
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