Presentation
5 March 2021 Light scattering measurements of retinal biomarkers of Alzheimer’s disease guided by low-cost optical coherence tomography
Author Affiliations +
Abstract
We present results from depth-resolved light scattering measurements of triple transgenic mouse retinas for Alzheimer’s Disease (AD) using a multimodal coherent imaging system. Use of a co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT) system allows unique analysis that is otherwise unavailable using a single modality to provide complementary information on tissue structural changes associated with AD. This abstract summarizes the light scattering parameters drawn using this system at selective retinal layers guided by OCT image segmentation. Future developments of this combined system for human retinal imaging, which involve a low-cost OCT engine, are also discussed.
Conference Presentation
© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Ge Song, Zachary A. Steelman, Stella Finkelstein, Ziyun Yang, Ludovic Martin, Kengyeh K. Chu, Sina Farsiu, Vadim Y. Arshavsky, and Adam Wax "Light scattering measurements of retinal biomarkers of Alzheimer’s disease guided by low-cost optical coherence tomography", Proc. SPIE 11657, Biomedical Applications of Light Scattering XI, 116570E (5 March 2021); https://doi.org/10.1117/12.2576911
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KEYWORDS
Light scattering

Imaging systems

Alzheimer's disease

Optical coherence tomography

Optical testing

Scatter measurement

Coherence imaging

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