Translator Disclaimer
Presentation
5 March 2021 Surface enhanced Raman scattering (SERS) nanoparticles for rapid chemical analysis of tumor-associated extracellular vesicles (EVs)
Author Affiliations +
Abstract
Sensitive and specific detection of biomaterials packaged in exosomes and related extracellular vesicles (EVs) has the potential to revolutionize cancer diagnosis and monitoring. Yet current methods cannot readily distinguish tumor-associated EVs. Surface-enhanced Raman spectroscopy (SERS) represents a promising tool to address current limitations, but are challenging to implement in whole biofluids. Here we outline a simple SERS assay combining nanoparticles with biofluids purified to various extent. We measure variation between clinical samples of head and neck cancer and demonstrate that there is a trade-off between useful molecular information from purified EVs versus the time, cost, and difficulty of isolation procedures.
Conference Presentation
© (2021) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Randy Carney, Tatu Rojalin, Hanna Koster, Hannah J. O'Toole, and Sebastian Wachsmann-Hogiu "Surface enhanced Raman scattering (SERS) nanoparticles for rapid chemical analysis of tumor-associated extracellular vesicles (EVs)", Proc. SPIE 11659, Colloidal Nanoparticles for Biomedical Applications XVI, 116590H (5 March 2021); https://doi.org/10.1117/12.2577297
PROCEEDINGS
PRESENTATION


SHARE
Advertisement
Advertisement
Back to Top