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5 March 2021 Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production
Brandon Gaitan, Rosalie Elespuru, Ellen Oskoui, Mariam Adwan, Anqi He, Huang-Chiao Huang, Yu Chen, Joshua Pfefer
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Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 116600A (2021) https://doi.org/10.1117/12.2579521
Event: SPIE BiOS, 2021, Online Only
Abstract
Recent advances in optical imaging have the potential to significantly improve patient outcomes. Among the most promising approaches under development is contrast-enhanced fluorescence imaging, which can be performed with molecular targeting to enhance tumor visualization. One key issue that has not been rigorously addressed is the potential phototoxicity of these fluorophores. In this study, we have used a commercial cell-free assay to qualify the singlet oxygen production rate in approved (ICG, Methylene Blue) and unapproved (IRDye700, IRDye800) fluorophores. Results shed light on the relative phototoxicity of each agent and will help to establish standardized methods for photochemical safety testing.
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Brandon Gaitan, Rosalie Elespuru, Ellen Oskoui, Mariam Adwan, Anqi He, Huang-Chiao Huang, Yu Chen, and Joshua Pfefer "Quantifying the photochemical damage potential of fluorescence contrast agents: singlet oxygen production", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 116600A (5 March 2021); https://doi.org/10.1117/12.2579521
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KEYWORDS
Oxygen
Luminescence
Industrial chemicals
Molecules
Safety
Molecular imaging
Optical imaging
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