Photonics-enabled lateral flow assay diagnostics

Daniel J. Steiner; Benjamin L. Miller

doi:10.1117/12.2582768

5 March 2021 Photonics-enabled lateral flow assay diagnostics

Proceedings Volume 11662, Frontiers in Biological Detection: From Nanosensors to Systems XIII; 116620F (2021) https://doi.org/10.1117/12.2582768
Event: SPIE BiOS, 2021, Online Only

Abstract

Point-of-Care diagnostics are instrumental to patient care and are broadly applied in the clinical setting. The simplest such device is the lateral flow assay, which is used to influence clinical decisions ranging from pregnancy to malarial infection. Lateral flow assays are ubiquitous; however, they are semi-quantitative, require labeled reagents, and are often less sensitive than comparable clinical laboratory technology. We hypothesize that an attractive method to introduce label-free quantification to Point-of-Care diagnostics is to couple them to photonic sensors. Photonic sensors are attractive as biological measurement tools, as they have low size, weight, and power requirements while providing high sensitivity. In this manuscript we describe post-processing of foundry-prepared photonic sensor chips in preparation for integration with a lateral flow format.

Conference Presentation

Citation Download Citation

Daniel J. Steiner and Benjamin L. Miller "Photonics-enabled lateral flow assay diagnostics", Proc. SPIE 11662, Frontiers in Biological Detection: From Nanosensors to Systems XIII, 116620F (5 March 2021); https://doi.org/10.1117/12.2582768

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