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The challenge for biosensors is to achieve high performance and multiple functionalities at low cost, which includes the source and readout instrumentation. Here, we describe a sensor modality utilizing guided mode resonances that can detect multiple markers for infection, that combines the sensor chip and spectrometer in a single chip and that can achieve a limit of detection as low as 1pg/ml. This performance is equivalent or better than laboratory-based techniques yet the sensor and instrumentation can be made entirely from low-cost components.
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Thomas F. Krauss, "High performance multifunctional low-cost biosensors," Proc. SPIE 11796, Active Photonic Platforms XIII, 117961W (3 August 2021); https://doi.org/10.1117/12.2595200