3D Cell-Rotation using Multi-Core Fiber-based Lab-on-a-Chip and Wavefront Shaping

Jürgen W. Czarske

doi:10.1117/12.2596236

1 August 2021 3D Cell-Rotation using Multi-Core Fiber-based Lab-on-a-Chip and Wavefront Shaping

Jürgen W. Czarske

Proceedings Volume 11798, Optical Trapping and Optical Micromanipulation XVIII; 117981F (2021) https://doi.org/10.1117/12.2596236
Event: SPIE Nanoscience + Engineering, 2021, San Diego, California, United States

Abstract

Optical dual-beam trapping is a vital tool in biology. However, a precise rotation of large cells in 3D about arbitrary axes has not been reported yet with dual-beam traps. We introduce a novel multi-core fiber-based dual-beam optical trap using wavefront shaping. Real-time controlled rotation of HL60 cells for cancer studies is demonstrated. For the first time, the orientation of the cell can be precisely controlled about all 3D axes in a dual beam trap. Multi-core fibers provide much higher flexibility beyond the bulky optics, enabling lab-on-a-chip applications and can be easily integrated for applications like non-invasive refractive index tomography and cell-elasticity measurements.

Conference Presentation

Citation Download Citation

Jürgen W. Czarske "3D Cell-Rotation using Multi-Core Fiber-based Lab-on-a-Chip and Wavefront Shaping", Proc. SPIE 11798, Optical Trapping and Optical Micromanipulation XVIII, 117981F (1 August 2021); https://doi.org/10.1117/12.2596236

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