Diffuse optical spectroscopic imaging of the human lactating breast

Nienke Bosschaart; Johanna R. de Wolf; Sjoukje M. Schoustra; Miriam van de Hoek; Anaïs Leproux; Ola Abdalsalam; Wen-Pin Chen; Christine E. McLaren; Bruce J. Tromberg; Thomas D. O'Sullivan

doi:10.1117/12.2615233

9 December 2021 Diffuse optical spectroscopic imaging of the human lactating breast

Nienke Bosschaart, Johanna R. de Wolf, Sjoukje M. Schoustra, Miriam van de Hoek, Anaïs Leproux, Ola Abdalsalam, Wen-Pin Chen, Christine E. McLaren, Bruce J. Tromberg, Thomas D. O'Sullivan

Author Affiliations +

Proceedings Volume 11920, Diffuse Optical Spectroscopy and Imaging VIII; 119200N (2021) https://doi.org/10.1117/12.2615233
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

Breastfeeding plays a crucial role in public health, but relatively few imaging and sensing technologies are employed to study human lactation physiology. As a consequence, many breastfeeding problems are not well understood. We hypothesize that diffuse optical spectroscopic imaging (DOSI) can potentially reveal important physiological parameters that help to define milk synthesis and secretion: glandular tissue content, hemodynamics and milk ejection. The aim of this study is to investigate the sensitivity of DOSI to these physiological parameters in (i) a case study (1 subject) on mammary involution of the lactating breast to its pre-pregnant state and (ii) a pilot study during milk extraction with a breast pump (4 lactating subjects, 5 non-lactating subjects). For the case study, the measured changes in the DOSI parameters (water, lipid, hemoglobin concentration) were consistent with the gradual replacement of fibro-glandular tissue by adipose tissue and vascular regression during mammary involution. For the pilot study, the measured changes in the DOSI parameters correlated with the extracted milk volume and occurrence of the milk ejection reflex. In conclusion, DOSI is sensitive to human lactation physiology, which can potentially aid to obtaining an in-depth understanding on the origin and treatment of breastfeeding problems.

Citation Download Citation

Nienke Bosschaart, Johanna R. de Wolf, Sjoukje M. Schoustra, Miriam van de Hoek, Anaïs Leproux, Ola Abdalsalam, Wen-Pin Chen, Christine E. McLaren, Bruce J. Tromberg, and Thomas D. O'Sullivan "Diffuse optical spectroscopic imaging of the human lactating breast", Proc. SPIE 11920, Diffuse Optical Spectroscopy and Imaging VIII, 119200N (9 December 2021); https://doi.org/10.1117/12.2615233

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Breast

Tissues

Spectroscopy

Diffuse optical imaging

Scattering

Optical spectroscopy

Imaging spectroscopy

Show All Keywords

Keywords/Phrases

Search In:

Publication Years