Non-convex optimization with spherical aberration compensation for efficient excitation in two-photon optogenetics

Cheng Jin; Chi Liu; Ruheng Shi; Lingjie Kong

doi:10.1117/12.2615642

3 December 2021 Non-convex optimization with spherical aberration compensation for efficient excitation in two-photon optogenetics

Cheng Jin, Chi Liu, Ruheng Shi, Lingjie Kong

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Proceedings Volume 11921, Emerging Technologies for Cell and Tissue Characterization; 119210M (2021) https://doi.org/10.1117/12.2615642
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

To stimulate neural ensemble selectively at high resolution, we propose non-convex optimization with spherical aberration compensation algorithm for two-photon optogenetics, which achieves high excitation efficiency and precise axial positioning.

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Cheng Jin, Chi Liu, Ruheng Shi, and Lingjie Kong "Non-convex optimization with spherical aberration compensation for efficient excitation in two-photon optogenetics", Proc. SPIE 11921, Emerging Technologies for Cell and Tissue Characterization, 119210M (3 December 2021); https://doi.org/10.1117/12.2615642

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KEYWORDS

Optogenetics

Detection and tracking algorithms

Monochromatic aberrations

Computer generated holography

Optimization (mathematics)

Point spread functions

Superposition

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