A simple Maxwellian optical system to investigate the photoreceptors contribution to pupillary light reflex

Giovanni Gibertoni; Valentina Di Pinto; Stefano Cattini; Federico Tramarin; Martial Geiser; Luigi Rovati

doi:10.1117/12.2608129

4 March 2022 A simple Maxwellian optical system to investigate the photoreceptors contribution to pupillary light reflex

Giovanni Gibertoni, Valentina Di Pinto, Stefano Cattini, Federico Tramarin, Martial Geiser, Luigi Rovati

Author Affiliations +

Proceedings Volume 11941, Ophthalmic Technologies XXXII; 119410G (2022) https://doi.org/10.1117/12.2608129
Event: SPIE BiOS, 2022, San Francisco, California, United States

Conference Poster

Abstract

The three classes of photoreceptors cones, rods, and intrinsically photosensitive retinal ganglion cells (ipRGCs) contribute to the pupillary light reflex (PLR). The Silent Substitution technique has been proposed to analyze the contribution of individual photoreceptor to PLR. Through the usage of properly selected pairs of light stimuli, this approach allows stimulating a single class of photoreceptors while keeping the activation of all the others constant. In this way, it is possible to understand the single photoreceptors class effect on both image-forming and non-image-forming functions of the human eyes. In this work, a simple approach to perform the Silent Substitution technique is presented and tested. The instrumentation has been designed with four primaries RGBY fiber-coupled LEDs and a double lens system to achieve a Maxwellian-View like optical system. Preliminary tests were conducted on three volunteers in which the PLRs induced by melanopic and chloropic stimulation were measured. The preliminary results confirm the expectations, the light-adapted pupil diameter is principally regulated by the activation level of the melanopsin-expressing ipRGCs photoreceptors, while conedriven induced pupil responses to peak in color contrast are transitory, reverting to the light-adapted baseline pupil diameter more rapidly in respect to melanopsin counterpart.

Conference Presentation

Citation Download Citation

Giovanni Gibertoni, Valentina Di Pinto, Stefano Cattini, Federico Tramarin, Martial Geiser, and Luigi Rovati "A simple Maxwellian optical system to investigate the photoreceptors contribution to pupillary light reflex", Proc. SPIE 11941, Ophthalmic Technologies XXXII, 119410G (4 March 2022); https://doi.org/10.1117/12.2608129

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