In-vivo photodynamic therapy dosimeter

J. Brian Dunn; P. Cusimano; Daniel R. Doiron; Charles J. Gomer; A. Edward Profio

doi:10.1117/12.17648

1 July 1990 In-vivo photodynamic therapy dosimeter

J. Brian Dunn, P. Cusimano, Daniel R. Doiron, Charles J. Gomer, A. Edward Profio

Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17648
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

A fiberoptic isotropic probe system has been developed to measure both the Space Irradiance (SI) and Fluorescence (F) within tissue during Photodynamic Therapy (PDT). The probe is 0.8mm in diameter. The system has a SI sensitivity of 0.1 mW/cm2 and a F sensitivity of 0.1 microgram per milliliter of DHE in a tissue phantom solution. It also provides for the time integrated SI and F and a ratio of the F to SI. A biological response study is being undertaken using DHE to determine the correlation of therapeutic response with drug dose, light dose, integrated space irradiance, and integrated fluorescence in a standardized animal tumor model. Description of the device and its performance will be presented along with preliminary results of animal tumor model studies.

Citation Download Citation

J. Brian Dunn, P. Cusimano, Daniel R. Doiron, Charles J. Gomer, and A. Edward Profio "In-vivo photodynamic therapy dosimeter", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); https://doi.org/10.1117/12.17648

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