Evaluation of the influence of the matrix effects of blood and serum on the optical properties of luminescent quantum dots

Tatiana S. Ponomaryova; Anastasiya S. Novikova; Daniil D. Drozd; Pavel D. Strokin; Olga A. Goryacheva; Artem A. Bakal; Irina Y. Goryacheva

doi:10.1117/12.2626115

29 April 2022 Evaluation of the influence of the matrix effects of blood and serum on the optical properties of luminescent quantum dots

Tatiana S. Ponomaryova, Anastasiya S. Novikova, Daniil D. Drozd, Pavel D. Strokin, Olga A. Goryacheva, Artem A. Bakal, Irina Y. Goryacheva

Author Affiliations +

Proceedings Volume 12192, Optical Technologies for Biology and Medicine; 121920I (2022) https://doi.org/10.1117/12.2626115
Event: XXV Annual Conference Saratov Fall Meeting 2021; and IX Symposium on Optics and Biophotonics, 2021, Saratov, Russian Federation

Abstract

In this paper, we report the synthesis of hydrophilic luminescent quantum dots (QDs) of the core/shell structure using two approaches: high-temperature organic synthesis of CdZnSeS/ZnS and aqueous synthesis of AgInS/ZnS. Dihydrolipoic and thioglycolic acids have been used as surface ligands to impart hydrophilic properties. The influence of whole blood and serum on the optical properties of both types of QDs was evaluated for their application in blood analysis. It has been shown that AgInS/ZnS QDs with emission in the red spectral region (λ_PL = 638 nm) remained the most stable in whole blood samples and its optimal dilutions (up to 1:100, inclusive). Whereas CdZnSeS/ZnS fluorescent in the green region of the spectrum (λ_PL = 530 nm) showed the best signal of fluorescence (PL) intensity in blood serum samples.

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Tatiana S. Ponomaryova, Anastasiya S. Novikova, Daniil D. Drozd, Pavel D. Strokin, Olga A. Goryacheva, Artem A. Bakal, and Irina Y. Goryacheva "Evaluation of the influence of the matrix effects of blood and serum on the optical properties of luminescent quantum dots", Proc. SPIE 12192, Optical Technologies for Biology and Medicine, 121920I (29 April 2022); https://doi.org/10.1117/12.2626115

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KEYWORDS

Blood

Optical properties

Quantum dots

Zinc

Luminescence

Silver

Sodium

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