A comparison of brain perfusion sensitivity achievable by diffuse correlation spectroscopy versus speckle contrast optical spectroscopy

Stefan A. Carp; Michell B. Robinson; Xiaojun Cheng; David A. Boas; Maria A. Franceschini

doi:10.1117/12.2650873

17 March 2023 A comparison of brain perfusion sensitivity achievable by diffuse correlation spectroscopy versus speckle contrast optical spectroscopy

Stefan A. Carp, Michell B. Robinson, Xiaojun Cheng, David A. Boas, Maria A. Franceschini

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Proceedings Volume 12364, Clinical and Translational Neurophotonics 2023; 1236408 (2023) https://doi.org/10.1117/12.2650873
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Diffuse correlation spectroscopy (DCS) offers non-invasive measurements of tissue perfusion and is increasingly broadly applied in human subject research, in particular in the neuromonitoring arena. However, signal to noise (SNR) limitations have prompted great interest in alternative instrumentation approaches to address this issue, such as the speckle contrast optical spectroscopy (SCOS) technique which uses spatial multi-speckle contrast to estimate blood flow. Here we present a simulation study of the brain perfusion sensitivity achievable by each method on adults, to guide the use of SCOS vs DCS approaches in future studies. We find that SCOS brain sensitivity is comparable to DCS.

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Stefan A. Carp, Michell B. Robinson, Xiaojun Cheng, David A. Boas, and Maria A. Franceschini "A comparison of brain perfusion sensitivity achievable by diffuse correlation spectroscopy versus speckle contrast optical spectroscopy", Proc. SPIE 12364, Clinical and Translational Neurophotonics 2023, 1236408 (17 March 2023); https://doi.org/10.1117/12.2650873

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KEYWORDS

Speckle

Brain

Optical spectroscopy

Spectroscopy

Signal to noise ratio

Human subjects

Laser speckle contrast imaging

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