27 April 2023Quantifying hypoxia with diffuse reflectance spectroscopy for advanced prognostication and real-time response monitoring in rectal cancer: an in vivo feasibility study
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
Tumour hypoxia is a critical factor in treatment failure and resistance, and its accurate measurement with diffuse reflectance spectroscopy (DRS) could be used for prognostic and response monitoring purposes. In this in vivo characterisation study, we sequentially measured oxygenation trends over the entire course of tumour growth in mice using a multi-depth, fibre-optic DRS probe. Results demonstrated a clear downtrend in oxygenation over time. This progression was not always linear, with significant heterogeneity over time and between mice. Our findings will be further validated against gold standards prior to investigating whether hypoxia can be used to predict radiotherapy responses.
Teddy Fletcher,Elena Monfort-Sanchez,Meysam Keshavarz,James Avery,Hutan Ashrafian,Ara W. Darzi, andAlex J. Thompson
"Quantifying hypoxia with diffuse reflectance spectroscopy for advanced prognostication and real-time response monitoring in rectal cancer: an in vivo feasibility study", Proc. SPIE 12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, 1237206 (27 April 2023); https://doi.org/10.1117/12.2648827
ACCESS THE FULL ARTICLE
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
The alert did not successfully save. Please try again later.
Teddy Fletcher, Elena Monfort-Sanchez, Meysam Keshavarz, James Avery, Hutan Ashrafian, Ara W. Darzi, Alex J. Thompson, "Quantifying hypoxia with diffuse reflectance spectroscopy for advanced prognostication and real-time response monitoring in rectal cancer: an in vivo feasibility study," Proc. SPIE 12372, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXIII, 1237206 (27 April 2023); https://doi.org/10.1117/12.2648827