Silicon photonic chip-based biosensor for COVID-19 and flu detection with high sensitivity and specificity

Shupeng Ning; Hao-Chen Chang; Kang-Chieh Fan; May H. Hlaing; Sourabh Jain; Jackson Carmichael; Lauren Head; Devangshu Goswami; Sasid Sriwattana; Hayden Pietsch; Savithri H Ramamoorthy; Ray T. Chen

doi:10.1117/12.2660407

14 March 2023 Silicon photonic chip-based biosensor for COVID-19 and flu detection with high sensitivity and specificity

Shupeng Ning, Hao-Chen Chang, Kang-Chieh Fan, May H. Hlaing, Sourabh Jain, Jackson Carmichael, Lauren Head, Devangshu Goswami, Sasid Sriwattana, Hayden Pietsch, Savithri H Ramamoorthy, Ray T. Chen

Author Affiliations +

Proceedings Volume 12444, Ultra-High-Definition Imaging Systems VI; 1244407 (2023) https://doi.org/10.1117/12.2660407
Event: SPIE OPTO, 2023, San Francisco, California, United States

Abstract

Since the end of 2021, Omicron, the new variant of SARS-CoV-2, has continued to spread as the predominant strain of COVID-19. Compared to previous variants, Omicron causes milder symptoms, which are similar to symptoms of other common respiratory infections, such as flu. In this work, we develop a silicon photonic chip-based biosensor for COVID-19 and flu detection using subwavelength grating micro-ring resonator. The biosensor realizes the detection of two pathogens with high sensitivity (1.31 fg/mL) and specificity. Besides, the microfluidic channel offers a promising solution for point-of-care detection.

Conference Presentation

Citation Download Citation

Shupeng Ning, Hao-Chen Chang, Kang-Chieh Fan, May H. Hlaing, Sourabh Jain, Jackson Carmichael, Lauren Head, Devangshu Goswami, Sasid Sriwattana, Hayden Pietsch, Savithri H Ramamoorthy, and Ray T. Chen "Silicon photonic chip-based biosensor for COVID-19 and flu detection with high sensitivity and specificity", Proc. SPIE 12444, Ultra-High-Definition Imaging Systems VI, 1244407 (14 March 2023); https://doi.org/10.1117/12.2660407

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