Photon counting spectral computed tomography in diagnosis of joint conditions using novel bismuth contrast agent

Abhisek Bhattarai; Jamie Guan-Tai Lok; Hongzhe Sun; Varut Vardhanabhuti

doi:10.1117/12.2653234

7 April 2023 Photon counting spectral computed tomography in diagnosis of joint conditions using novel bismuth contrast agent

Abhisek Bhattarai, Jamie Guan-Tai Lok, Hongzhe Sun, Varut Vardhanabhuti

Author Affiliations +

Proceedings Volume 12463, Medical Imaging 2023: Physics of Medical Imaging; 1246305 (2023) https://doi.org/10.1117/12.2653234
Event: SPIE Medical Imaging, 2023, San Diego, California, United States

Abstract

Current diagnostic techniques detect osteoarthritis too late for non-surgical treatment. This study examines the use of contrast-enhanced photon-counting spectral computed tomography (PC-SCT) for diagnosis of joint conditions. The multi-material decomposition capability and high-resolution imaging of PC-SCT with a novel bismuth-contrast agent allowed imaging of cartilage and bone structure, information on the volumetric distribution of proteoglycan and water composition in cartilage, and calcium deposits in bone for improved joint diagnosis. With PC-SCT, osteoarthritis can be monitored and treated by imaging the entire joint structure and components in one scan.

Conference Presentation

Citation Download Citation

Abhisek Bhattarai, Jamie Guan-Tai Lok, Hongzhe Sun, and Varut Vardhanabhuti "Photon counting spectral computed tomography in diagnosis of joint conditions using novel bismuth contrast agent", Proc. SPIE 12463, Medical Imaging 2023: Physics of Medical Imaging, 1246305 (7 April 2023); https://doi.org/10.1117/12.2653234

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