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Synovial inflammation is increasingly appreciated as a key feature in osteoarthritis pathogenesis and pain, but the gold standard method of measuring synovitis (MRI) is inaccessible in routine clinical care. 3-dimensional ultrasound could present a potential solution if it demonstrates good measurement properties in suprapatellar recess synovitis. We recruited five knee osteoarthritis patients awaiting knee replacement, who received both MRI and 3DUS imaging of the knee on the same day. By manually segmenting synovitis on 3DUS and MRI images, we found that 3DUS has excellent intra/inter-rater reliability for synovitis volume and differs from MRI segmentations by approximately 26.73%.
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Robert Dima, Carla du Toit, Jennifer Polus, Trevor Birmingham, C. Thomas Appleton, Aaron Fenster, "Three-dimensional ultrasound for quantitation of synovial tissue volume in knee osteoarthritis," Proc. SPIE 12470, Medical Imaging 2023: Ultrasonic Imaging and Tomography, 124700D (10 April 2023); https://doi.org/10.1117/12.2653851