Optical coherence tomography angiography for chronic venous insufficiency and venous leg ulcer

Giulia Rotunno; Julia Deinsberger; Kristen M. Meiburger; Lisa Krainz; Lukasz Bugyi; Richard Haindl; Rainer Leitgeb; Benedikt Weber; Wolfgang Drexler; Mengyang Liu

doi:10.1117/12.2670767

11 August 2023 Optical coherence tomography angiography for chronic venous insufficiency and venous leg ulcer

Giulia Rotunno, Julia Deinsberger, Kristen M. Meiburger, Lisa Krainz, Lukasz Bugyi, Richard Haindl, Rainer Leitgeb, Benedikt Weber, Wolfgang Drexler, Mengyang Liu

Author Affiliations +

Proceedings Volume 12627, Translational Biophotonics: Diagnostics and Therapeutics III; 126271R (2023) https://doi.org/10.1117/12.2670767
Event: European Conferences on Biomedical Optics, 2023, Munich, Germany

Abstract

Chronic venous insufficiency (CVI) ranks among the most common health care issues worldwide. The current diagnosis of CVI is done by clinical examination and duplex ultrasound, which can only detect visible physical changes and deeper vascular structures whereas the superficial cutaneous vasculature cannot be resolved. There is indeed a lack of information that can potentially be extracted from the cutaneous microvasculature of patients affected by CVI. In this work, we designed and applied an optical coherence tomography angiography (OCTA) system, which is customized for lower extremity imaging of patients. Featuring fast imaging speed, large field of view, high spatial resolution, and most importantly non-invasiveness, this OCTA system was successfully applied in CVI and venous leg ulcer patient imaging. Using the OCTA results acquired from a cohort of 27 human subjects, we can clearly distinguish the vascular patterns uniquely associated with various stages of CVI. The findings of this study give an unexplored indicator to the disease of CVI and venous leg ulcer. With more patients to be recruited, we believe that OCTA imaging results for CVI can be used as a powerful tool in CVI screening and diagnosis.

Citation Download Citation

Giulia Rotunno, Julia Deinsberger, Kristen M. Meiburger, Lisa Krainz, Lukasz Bugyi, Richard Haindl, Rainer Leitgeb, Benedikt Weber, Wolfgang Drexler, and Mengyang Liu "Optical coherence tomography angiography for chronic venous insufficiency and venous leg ulcer", Proc. SPIE 12627, Translational Biophotonics: Diagnostics and Therapeutics III, 126271R (11 August 2023); https://doi.org/10.1117/12.2670767

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
3 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Angiography

Imaging systems

Optical coherence tomography

Human subjects

Medicine

Spatial resolution

Ultrasonography

Show All Keywords

Keywords/Phrases

Search In:

Publication Years