Improvement of printed circuit-board-based digital microfluidic chip and its application in peptide screening

Xingyue Wu; Dongbao Tang; Luxuan Liu; Zhaoyuan Jia; Yuyu Tan

doi:10.1117/12.2687405

28 August 2023 Improvement of printed circuit-board-based digital microfluidic chip and its application in peptide screening

Xingyue Wu, Dongbao Tang, Luxuan Liu, Zhaoyuan Jia, Yuyu Tan

Author Affiliations +

Proceedings Volume 12724, Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023); 127240H (2023) https://doi.org/10.1117/12.2687405
Event: Second International Conference on Biomedical and Intelligent Systems (IC-BIS2023), 2023, Xiamen, China

Abstract

This paper proposes an improved digital microfluidics (DMF) chip based on a printed circuit board (PCB) to realize the precise control of droplets. Solder mask layer was introduced to the chip as the dielectric layer, and this way can simplify the preparation processes of the chip, and the chip offers reasonable control of the droplet. Combined with the external module, the S protein peptide was screened on the chip. As a result, this PCB-based chip provided a new tool for droplet manipulation. It may have potential applications in drug screening, especially in the field with many repetitive operations.

Citation Download Citation

Xingyue Wu, Dongbao Tang, Luxuan Liu, Zhaoyuan Jia, and Yuyu Tan "Improvement of printed circuit-board-based digital microfluidic chip and its application in peptide screening", Proc. SPIE 12724, Second International Conference on Biomedical and Intelligent Systems (IC-BIS 2023), 127240H (28 August 2023); https://doi.org/10.1117/12.2687405

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