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27 November 2023 Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury
Weitao Li, Xinping Qi, Han Zhang, Yameng Zhang, Jin Hu, Yamin Yang, Zhiyu Qian
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Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 1277004 (2023) https://doi.org/10.1117/12.2687355
Event: SPIE/COS Photonics Asia, 2023, Beijing, China
Abstract
Currently, intracranial pressure (ICP) is the primary clinical monitoring parameter for traumatic brain injury (TBI). However, during the hyperacute phase of TBI, ICP value lags behind changes of brain temperature (BT) and neurometabolic activity. This is due to the compensatory capacity of the intracranial space. Here, we explored BT changes and concentration changes of cytochrome c (∆Ccytc) during the hyper-acute phase of TBI. Nine mice were randomly divided into control group, mild TBI group, and severe TBI group. The mouse TBI model is created by using various levels of striking force. The strike device is designed and improved based on Feeney's free fall model. BT can be measured by a minimally invasive measurement probe, allowing for the observation of changes in both time and spatial distribution. ∆Ccytc was calculated using an intrinsic optical signal imaging system (IOSI). The relationship between BT and ∆Ccytc was analyzed during the development of mice TBI models.
(2023) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Weitao Li, Xinping Qi, Han Zhang, Yameng Zhang, Jin Hu, Yamin Yang, and Zhiyu Qian "Study on the relationship between brain temperature and cytochrome c in hyperacute phase of mouse traumatic brain injury", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 1277004 (27 November 2023); https://doi.org/10.1117/12.2687355
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KEYWORDS
Traumatic brain injury
Brain
Animals
Chromophores
Imaging systems
Injuries
Intrinsic optical signal imaging
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