Therapeutic outcome in relation to port-wine stains' morphological parameters through OCTA

Yidi Liu; Ying Gu; Haixia Qiu

doi:10.1117/12.2692172

29 November 2023 Therapeutic outcome in relation to port-wine stains' morphological parameters through OCTA

Yidi Liu, Ying Gu, Haixia Qiu

Proceedings Volume 12770, Optics in Health Care and Biomedical Optics XIII; 127703L (2023) https://doi.org/10.1117/12.2692172
Event: SPIE/COS Photonics Asia, 2023, Beijing, China

Conference Poster

Abstract

Purpose: Use the OCTA to figure out the relationship between PWS structure and therapeutic effect. Method: Before and immediately after V-PDT, OCTA was used to scan the skin of the same part of 80 patients. The efficacy was evaluated colorimetrically 3-6 months after V-PDT. The relationship between PWS lesion structure and V-PDT efficacy was analyzed. The lesion structural factors affecting the prognosis of V-PDT were analyzed using a multi-factor binary Logistic regression model. Result: Among the total 80 PWS patients who received V-PDT, 22 were non-responders and 58 got improved. Comparing the structure in non-responders and improved patients, non-responders had a thicker epidermis (P=0.0012), and a higher proportion of 10-30μm vessels (P=0.0014), higher average density ratio between shallow and deep layers (P=0.0006), higher proportion of vertical vessels (P<0.0001), and no decrease of number of vessels immediately after V-PDT (P=0.002). Conclusion: Multiple structural factors can significantly affect the efficacy of V-PDT.

Citation Download Citation

Yidi Liu, Ying Gu, and Haixia Qiu "Therapeutic outcome in relation to port-wine stains' morphological parameters through OCTA", Proc. SPIE 12770, Optics in Health Care and Biomedical Optics XIII, 127703L (29 November 2023); https://doi.org/10.1117/12.2692172

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