CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 12853 > Article
Presentation
13 March 2024 Seeing metabolic changes in aging and disease with high-speed multimodal microscopy
Lingyan Shi, Hongje Jang, Yajuan Li, Zhi Li, Pegah Bagheri
Author Affiliations +
Proceedings Volume 12853, High-Speed Biomedical Imaging and Spectroscopy IX; 1285307 (2024) https://doi.org/10.1117/12.3006015
Event: SPIE BiOS, 2024, San Francisco, California, United States
Abstract
Our high-speed multimodal imaging platform combines stimulated Raman Scattering (SRS), multiphoton fluorescence (MPF), and second harmonic generation (SHG) to explore metabolic activities of biomolecules in cells and tissues. Using the A-PoD algorithm, we achieve super-resolution imaging, while deuterium oxide probing enhances SRS imaging. The Correlation Coefficient Mapping (CoCoMap) technique helps understand coordination and regulation of metabolic activities. This tool enables early disease detection, prognosis, and therapeutic assessment, providing valuable insights into aging and metabolic diseases. Our approach revolutionizes metabolism visualization, advancing knowledge of biological processes and their implications in health and disease.
Conference Presentation
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Lingyan Shi, Hongje Jang, Yajuan Li, Zhi Li, and Pegah Bagheri "Seeing metabolic changes in aging and disease with high-speed multimodal microscopy", Proc. SPIE 12853, High-Speed Biomedical Imaging and Spectroscopy IX, 1285307 (13 March 2024); https://doi.org/10.1117/12.3006015
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Diseases and disorders
Visualization
Multimodal imaging
Second harmonic generation
Biomolecules
Correlation coefficients
Microscopy
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top