At-home measurement of blood biomarkers on the SiPhox Home silicon photonics platform

Kyle Preston; Guojun Chen; Cole A. Chapman; Sarat Gundavarapu; Ebrahim Aljohani; Armando Paredes Arroyo; Chi-Chen Lin; Alexander Vinitsky; Alana Gonzales; Ze Yin; Michael Dubrovsky; Diedrik Vermeulen

doi:10.1117/12.3001255

13 March 2024 At-home measurement of blood biomarkers on the SiPhox Home silicon photonics platform

Kyle Preston, Guojun Chen, Cole A. Chapman, Sarat Gundavarapu, Ebrahim Aljohani, Armando Paredes Arroyo, Chi-Chen Lin, Alexander Vinitsky, Alana Gonzales, Ze Yin, Michael Dubrovsky, Diedrik Vermeulen

Author Affiliations +

Proceedings Volume 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI; 1286104 (2024) https://doi.org/10.1117/12.3001255
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We demonstrate the capabilities of the SiPhox Home platform to measure blood biomarker concentrations such as a highsensitivity C-reactive protein (hsCRP) assay. The system consists of disposable biosensor cartridges which plug into a compact reader instrument. The reader contains a miniature low-cost swept-source laser and detection system which is designed to interrogate on-chip resonant or interferometric sensors, and we demonstrate excellent performance of manufactured readers compared to a gold-standard laboratory tunable laser. The cartridge includes a silicon photonics chip with 15 individually addressable microring resonator sensors which transduce molecular binding into a wavelength shift measured by the reader. We demonstrate both labeled and label-free ring resonator immunoassays running on our platform which can measure the relevant hsCRP concentration range of 0.2 – 10 μg/mL. In a preliminary method comparison study, 7 volunteers measured their hsCRP values at home by two methods: SiPhox Home, which displays results after only a 4-minute run time, and a commercially available mail-in blood test, which typically returns results in 3-5 business days. The results show a good correlation and demonstrate the potential for high-quality at-home measurement of blood biomarkers using manufacturable silicon photonics technology.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Kyle Preston, Guojun Chen, Cole A. Chapman, Sarat Gundavarapu, Ebrahim Aljohani, Armando Paredes Arroyo, Chi-Chen Lin, Alexander Vinitsky, Alana Gonzales, Ze Yin, Michael Dubrovsky, and Diedrik Vermeulen "At-home measurement of blood biomarkers on the SiPhox Home silicon photonics platform", Proc. SPIE 12861, Frontiers in Biological Detection: From Nanosensors to Systems XVI, 1286104 (13 March 2024); https://doi.org/10.1117/12.3001255

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