Mechanism of exendin-4 promoting bone regeneration

Yuxuan Guo

doi:10.1117/12.3013156

8 January 2024 Mechanism of exendin-4 promoting bone regeneration

Yuxuan Guo

Proceedings Volume 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023); 129240R (2024) https://doi.org/10.1117/12.3013156
Event: 3rd International Conference on Biological Engineering and Medical Science (ICBioMed2023), 2023, ONLINE, United Kingdom

Abstract

Exendin-4 is an analogue of glucagon-like peptide-1 (GLP-1) and has a good efficacy in the treatment of type II diabetes. Recently, some researchers have found that Exendin-4 can promote cell osteogenesis and angiogenesis, but the specific mechanism of its promotion of bone regeneration is not yet clear. This review focuses on the specific mechanisms by which Exendin-4 promotes osteogenesis in bone cells and stem cells, as well as its ability to induce endothelial cell migration, budding, and neovascularization, and promote angiogenesis. In addition, this article discusses some in vivo experiments using Exendin-4 alone or in combination with other materials. However, since its specific mechanism is not yet clear, and there is no clinical data to support it, a comprehensive understanding of the mechanism by which Exendin-4 promotes bone regeneration is of significant value for treatment of bone tissue damage in diabetic patients. This review also provides a certain direction and basis for the subsequent practical application of Exendin-4.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Yuxuan Guo "Mechanism of exendin-4 promoting bone regeneration", Proc. SPIE 12924, Third International Conference on Biological Engineering and Medical Science (ICBioMed2023), 129240R (8 January 2024); https://doi.org/10.1117/12.3013156

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KEYWORDS

Bone

Stem cells

Tissues

In vivo imaging

Osteoporosis

Glucose

Injuries

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