Geometric features of pulmonary arteries are associated with early progression and progression-free survival in small-cell lung cancer patients treated with chemotherapy and immunotherapy

Margalit G. Mitzner; Moinak Bhattacharya; Radhika Gutta; Chao Chen; Shirish M. Gadgeel; Prateek Prasanna

doi:10.1117/12.3008810

3 April 2024 Geometric features of pulmonary arteries are associated with early progression and progression-free survival in small-cell lung cancer patients treated with chemotherapy and immunotherapy

Margalit G. Mitzner, Moinak Bhattacharya, Radhika Gutta, Chao Chen, Shirish M. Gadgeel, Prateek Prasanna

Author Affiliations +

Proceedings Volume 12927, Medical Imaging 2024: Computer-Aided Diagnosis; 129270A (2024) https://doi.org/10.1117/12.3008810
Event: SPIE Medical Imaging, 2024, San Diego, California, United States

Abstract

We investigated whether geometric features of pulmonary arteries are associated with early progression or progression-free survival at twelve months following initiation of combined immunotherapy and chemotherapy treatment in patients with extensive stage small cell lung cancer (SCLC). We utilized pre-treatment Computerized Tomography (CT) scans of 64 patients’ lungs to create skeletonized networks of patients’ pulmonary arteries, and a machine learning model was used to determine associations of geometric and clinical features with treatment response and survival. Geometric analyses achieved a ROC-AUC of 0.63 ± 0.23 for the ipsilateral geometric model and 0.61 ± 0.13 for the geometric model incorporating geometric features from both lungs, both higher than that of the clinical model alone, 0.58 ± 0.08. Additionally, the combined clinical and geometric model yielded a ROC-AUC of 0.64 ± 0.25 for the ipsilateral model and 0.67 ± 0.10 for the model incorporating features from both lungs, both higher than that of the clinical model alone.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Margalit G. Mitzner, Moinak Bhattacharya, Radhika Gutta, Chao Chen, Shirish M. Gadgeel, and Prateek Prasanna "Geometric features of pulmonary arteries are associated with early progression and progression-free survival in small-cell lung cancer patients treated with chemotherapy and immunotherapy", Proc. SPIE 12927, Medical Imaging 2024: Computer-Aided Diagnosis, 129270A (3 April 2024); https://doi.org/10.1117/12.3008810

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