Terahertz time-domain spectroscopy imaging of pancreatic ductal adenocarcinoma tissues

Debamitra Chakraborty; Bradley N. Mills; Jing Cheng; Ivan V. Komissarov; Scott A. Gerber; Roman Sobolewski

doi:10.1117/12.3023034

18 June 2024 Terahertz time-domain spectroscopy imaging of pancreatic ductal adenocarcinoma tissues

Debamitra Chakraborty, Bradley N. Mills, Jing Cheng, Ivan V. Komissarov, Scott A. Gerber, Roman Sobolewski

Proceedings Volume 13010, Tissue Optics and Photonics III; 1301005 (2024) https://doi.org/10.1117/12.3023034
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Pancreatic ductal adenocarcinoma (PDAC) ranks among the malignancies with the highest fatality and morbidity rates. This is predominantly attributable to an absence of understanding the intricate and diverse microenvironment of the tumor. We use terahertz time-domain spectroscopy (THz-TDS) imaging in transmission geometry to probe ex-vivo the heterogenous microenvironment of the genetically modified murine PDAC tissue that closely resembles the PDAC heterogeneity in human malignancy. We introduced a maximum a-posteriori probability estimation algorithm to objectively the tumor’s heterogenous microenvironment using the average values of refractive index and absorption coefficient within the useable terahertz bandwidth as imaging markers. Direct comparison of stained histopathologic images and the refractive index and the absorption coefficient high-resolution, two-dimensional maps of the same PDAC samples confirms the high potential of the THz-TDS method for tumor tissue characterization.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Debamitra Chakraborty, Bradley N. Mills, Jing Cheng, Ivan V. Komissarov, Scott A. Gerber, and Roman Sobolewski "Terahertz time-domain spectroscopy imaging of pancreatic ductal adenocarcinoma tissues", Proc. SPIE 13010, Tissue Optics and Photonics III, 1301005 (18 June 2024); https://doi.org/10.1117/12.3023034

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available