Hierarchical phase-contrast tomography: a non-destructive multiscale imaging approach for whole human organs

J. Brunet; C. L. Walsh; P. Tafforeau; H. Dejea; A. C. Cook; A. Bellier; K. Engel; Danny D. Jonigk; M. Ackermann; P. D. Lee

doi:10.1117/12.3028717

23 October 2024 Hierarchical phase-contrast tomography: a non-destructive multiscale imaging approach for whole human organs

J. Brunet, C. L. Walsh, P. Tafforeau, H. Dejea, A. C. Cook, A. Bellier, K. Engel, Danny D. Jonigk, M. Ackermann, P. D. Lee

Author Affiliations +

Proceedings Volume 13152, Developments in X-Ray Tomography XV; 1315216 (2024) https://doi.org/10.1117/12.3028717
Event: Optical Engineering + Applications, 2024, San Diego, California, United States

Abstract

Achieving cellular-resolution imaging of intact human organs is critical for improving our understanding of anatomy and pathology. Traditional clinical imaging and histological methods often fail to provide both global and detailed views of entire organs. Hierarchical Phase-Contrast Tomography (HiP-CT), an approach leveraging the ESRF’s Extremely Brilliant Source upgrade to perform non-destructive, high-resolution imaging of intact human organs addresses these limitations. HiP-CT allows for whole organ scans at <20μm/voxel, with localized zooms down to 2μm/voxel, bridging the gap between clinical imaging and histology. This multi-scale capability enables detailed examination of anatomical structures and pathologies. We provide here the last developments of HiP-CT, along with various applications on human organs. HiP-CT has shown potential in research areas such as COVID-19 affected lungs and cardiac studies. Despite challenges like high radiation doses and data management, HiP-CT represents a significant advancement in biomedical imaging, with future research aiming to extend its application, correlative imaging upscale and downscale, and enhance data accessibility.

Conference Presentation

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

J. Brunet, C. L. Walsh, P. Tafforeau, H. Dejea, A. C. Cook, A. Bellier, K. Engel, Danny D. Jonigk, M. Ackermann, and P. D. Lee "Hierarchical phase-contrast tomography: a non-destructive multiscale imaging approach for whole human organs", Proc. SPIE 13152, Developments in X-Ray Tomography XV, 1315216 (23 October 2024); https://doi.org/10.1117/12.3028717

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