A colourimetric sensing based on MXene@Hemin nanoenzyme for the rapid detection of low-density lipoprotein

Tingting Yu; Weiru Bao; Guiyin Li

doi:10.1117/12.3052640

12 December 2024 A colourimetric sensing based on MXene@Hemin nanoenzyme for the rapid detection of low-density lipoprotein

Tingting Yu, Weiru Bao, Guiyin Li

Author Affiliations +

Proceedings Volume 13446, Sixth International Conference on Optoelectronic Science and Materials (ICOSM 2024); 1344614 (2024) https://doi.org/10.1117/12.3052640
Event: 6th International Conference on Optoelectronic Science and Materials (ICOSM 2024), 2024, Hefei, China

Abstract

The increase of low-density lipoprotein (LDL) concentration will increase the cholesterol content in blood, which will pose a serious threat to vascular health and lead to a series of cardiovascular diseases (CVD) with high mortality. In this study, a two-dimensional titanium carbide@hemin nanoenzyme (MXene@Hemin) with good peroxidase activity was prepared, and its enzymatic activity was verified. Then, the sandwich colorimetric aptamer sensor of LDLApt/LDL/MXene@Hemin-LDL_Apt was constructed and applied to the detection of actual human serum. Under optimal experimental conditions, the colorimetric aptamer sensor showed a good linear relationship with LDL concentration from 0.5 to 80.0 μg/mL with a minimum detection limit(LOD) of 0.277 μg/mL. In the detection of LDL concentration in actual serum samples, the relative standard deviation (RSD) and relative error (SD) of the sensor are 0.641%~6.717% and 0.428%~3.205%, respectively. It has good sensitivity and specificity, and provides a simple and sensitive means for the prevention and evaluation of cardiovascular diseases.

(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Tingting Yu, Weiru Bao, and Guiyin Li "A colourimetric sensing based on MXene@Hemin nanoenzyme for the rapid detection of low-density lipoprotein", Proc. SPIE 13446, Sixth International Conference on Optoelectronic Science and Materials (ICOSM 2024), 1344614 (12 December 2024); https://doi.org/10.1117/12.3052640

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available