Integrated optic device for biochemical sensing

Anthony A. Boiarski; Richard W. Ridgway; Larry S. Miller; Ballwant S. Bhullar

doi:10.1117/12.24797

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1 March 1991 Integrated optic device for biochemical sensing

Anthony A. Boiarski, Richard W. Ridgway, Larry S. Miller, Ballwant S. Bhullar

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Proceedings Volume 1368, Chemical, Biochemical, and Environmental Fiber Sensors II; (1991) https://doi.org/10.1117/12.24797
Event: SPIE Microelectronic Interconnect and Integrated Processing Symposium, 1990, San Jose, United States

Abstract

A novel immunosensor concept monitors antigen-antibody binding on the surface of a planar single-mode waveguide. The concept can be used as the basis for a label-free homogeneous immunoassay because only changes in the thickness and refractive index of the antigen-antibody layer are monitored by observing small changes in the effective index of the waveguide. BSA +anti- BSA binding was examined theoretically using a four-layer model and effective index measurements were obtained which agreed with the calculated values. Analysis indicated that the small effective index changes can possibly be measured with high sensitivity and at low cost using an integrated optic interferometer format.

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Anthony A. Boiarski, Richard W. Ridgway, Larry S. Miller, and Ballwant S. Bhullar "Integrated optic device for biochemical sensing", Proc. SPIE 1368, Chemical, Biochemical, and Environmental Fiber Sensors II, (1 March 1991); https://doi.org/10.1117/12.24797

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