Cluster model of protein molecule

Andrey Yuri Chikishev; Yu. I. Kuargin; Yuri A. Romanovsky; E. G. Shidlovskaya

doi:10.1117/12.57397

1 May 1991 Cluster model of protein molecule

Andrey Yuri Chikishev, Yu. I. Kuargin, Yuri A. Romanovsky, E. G. Shidlovskaya

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57397
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

The analysis of intradomain vibrations of the proteins in the 1011 -1O'3Hz range may be based on existence of domains or large clusters in the macromolecules connected by H-bonds and Van der Waals forces. As an example of such system we can consider the a-chymotrypsin 25 kD molecule with the two 12 kD subglobules. The active site of the enzyme molecule is located between the subglobules (Fig. la). The subglobular vibrations may lead to the lowering of the potential barrier for the proton transfer processes in the active site (Fig. 1 a,b)."2

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Andrey Yuri Chikishev, Yu. I. Kuargin, Yuri A. Romanovsky, and E. G. Shidlovskaya "Cluster model of protein molecule", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57397

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