Vibrational Raman optical activity of biological molecules

L. D. Barron; A. R. Gargaro; Lutz Hecht; Z. Q. Wen; W. Hug

doi:10.1117/12.57291

1 May 1991 Vibrational Raman optical activity of biological molecules

L. D. Barron, A. R. Gargaro, Lutz Hecht, Z. Q. Wen, W. Hug

Proceedings Volume 1403, Laser Applications in Life Sciences; (1991) https://doi.org/10.1117/12.57291
Event: Laser Applications in Life Sciences, 1990, Moscow, Russian Federation

Abstract

Advances in Raman optical activity (ROA) instrumentation based on the employment of a backscattering geometry together with a cooled CCD detector have now enhanced the sensitivity to the level necessary to provide vibrational ROA spectra of biological molecules in aqueous solution. Preliminary results on peptides and proteins show features originating in coupled Ca-H and N-H deformations of the peptide backbone which appear to be sensitive to the secondary conformation. Also carbohydrates show many features that appear to be characteristic of the central aspects of carbohydrate architecture with effects from the glycosidic link in di- and oligosaccharides particularly prominent. 1.

Citation Download Citation

L. D. Barron, A. R. Gargaro, Lutz Hecht, Z. Q. Wen, and W. Hug "Vibrational Raman optical activity of biological molecules", Proc. SPIE 1403, Laser Applications in Life Sciences, (1 May 1991); https://doi.org/10.1117/12.57291

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