In-vivo optical attenuation in normal rat brain and its implication in PDT

Qun Chen; Brian C. Wilson; Michael S. Patterson; Michael Chopp; Fred W. Hetzel

doi:10.1117/12.44054

1 June 1991 In-vivo optical attenuation in normal rat brain and its implication in PDT

Qun Chen, Brian C. Wilson, Michael S. Patterson, Michael Chopp, Fred W. Hetzel

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44054
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

Investigation is made of the optical attenuation depth in Fisher rat brain at different wavelengths and during PDT treatment. The attenuation depth gradually increased from 0.6 to 1.7 mm when the irradiating light wavelength increased from 450 nm to 710 nm. During PDT treatment (Photofrin II 48 hours prior to 633 nm, 5 mm diameter surface irradiation of 100 J/cm2 and 100 mW/cm2), the attenuation depth was found relatively constant (variation

Citation Download Citation

Qun Chen, Brian C. Wilson, Michael S. Patterson, Michael Chopp, and Fred W. Hetzel "In-vivo optical attenuation in normal rat brain and its implication in PDT", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44054

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