New sensitizers for PDT

Alan Raymond Morgan; Greta M. Garbo; T. Krivak; Marta Mastroianni; Nikolaos H. Petousis; T. St Clair; M. Weisenberger; Johan E. van Lier

doi:10.1117/12.44075

1 June 1991 New sensitizers for PDT

Alan Raymond Morgan, Greta M. Garbo, T. Krivak, Marta Mastroianni, Nikolaos H. Petousis, T. St Clair, M. Weisenberger, Johan E. van Lier

Author Affiliations +

Proceedings Volume 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques; (1991) https://doi.org/10.1117/12.44075
Event: Optics, Electro-Optics, and Laser Applications in Science and Engineering, 1991, Los Angeles, CA, United States

Abstract

For a number of well-defined reasons, research into the development of alternative photosensitizers to PhotofrinTM, for use in Photodynamic Therapy, continues. The efforts described in this paper cover the study of a number of sensitizers absorbing at different wavelengths, which may have selective applications in the field of photomedicine. In one approach, the use of tetraazoporphyrins (porphyrazines) as sensitizers is studied. Although related tetramacrocyclic systems such as porphyrins and phthalocyanines have been, and continue to be, well studied in this field, porphyrazines have, to-date, received little attention. In a second study, purpurins are examined as possible alternatives to PhotofrinTM. In a recent study, tissue distribution properties of tin etiopurpurin dichloride, as a function of time, were examined. Results indicate that this purpurin continues to show promise for applications in PDT.

Citation Download Citation

Alan Raymond Morgan, Greta M. Garbo, T. Krivak, Marta Mastroianni, Nikolaos H. Petousis, T. St Clair, M. Weisenberger, and Johan E. van Lier "New sensitizers for PDT", Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); https://doi.org/10.1117/12.44075

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