Improved instrumentation for photodynamic fluorescence detection of cancer

Reinhold Baumgartner; Peter Heil; Dieter Jocham; M. Kriegmair; Herbert G. Stepp; Eberhard Unsoeld

doi:10.1117/12.48231

1 November 1991 Improved instrumentation for photodynamic fluorescence detection of cancer

Reinhold Baumgartner, Peter Heil, Dieter Jocham, M. Kriegmair, Herbert G. Stepp, Eberhard Unsoeld

Proceedings Volume 1525, Future Trends in Biomedical Applications of Lasers; (1991) https://doi.org/10.1117/12.48231
Event: MedTech '91, 1991, Berlin, Germany

Abstract

A fluorescence-detection technique for cancer in human hollow organs has been developed based on endoscope-assisted two-wavelength excitation of the polyporphyrin Photofrin II in tissue. Due to the photosensitizing capability of the fluorescent tumormarket the applied dose is reduced to 0.4 mg/kg bw which avoids photosensitization of the patient''s skin. Fluorescence is detected either spectrally resolved by means of an optical multichannel analyzer or by imaging of diseased tissue areas with an intensified video system. The fluorescence pattern in the final image is presented with high contrast due to realtime subtraction of nonspecific background signals.

Citation Download Citation

Reinhold Baumgartner, Peter Heil, Dieter Jocham, M. Kriegmair, Herbert G. Stepp, and Eberhard Unsoeld "Improved instrumentation for photodynamic fluorescence detection of cancer", Proc. SPIE 1525, Future Trends in Biomedical Applications of Lasers, (1 November 1991); https://doi.org/10.1117/12.48231

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