Depth of necrosis induced by photodynamic therapy with sulfonated aluminum phthalocyanine in S180 fibrosarcoma of mice

Hong-Yu Yu; Rong-Chun Dong; Ji-Yao Chen; Huai-Xin Cai

doi:10.1117/12.137033

5 March 1993 Depth of necrosis induced by photodynamic therapy with sulfonated aluminum phthalocyanine in S₁₈₀ fibrosarcoma of mice

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, Huai-Xin Cai

Author Affiliations +

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137033
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

In view of explaining the results that AlSPC-PDT was more effective than HPD-PDT in destroying S₁₈₀ fibrosarcoma (diameter: 0.5 - 0.8 cm; thickness: 0.4 - 0.7 cm) transplanted in white mice, the depth of necrosis of S₁₈₀ sarcoma in mice in AlSPC-PDT was studied, compared with it in HPD-PDT. Two kinds of HPD were chosen as the control photosensitizers of AlSPC: Photofrin I (PI), and Photosensitizing drug-007 (PSD-007). The experimental tumors in mice were chosen with longitudinal diameters in the range of 0.8 - 1.0 cm and thickness in the range of 0.7 - 1.0 cm. A photosensitizer dose of 10 mg/kg was given (iv) for PI-PDT, PSD-007-PDT, and AlSPC-PDT. The dose of exposure light (600 - 750 nm) was 180 J/cm². The experimental mice were killed 48 h after PDT to get the tumor necrotic depth. The depth was 0.55 +/- 0.14 cm (0.30 - 0.85 cm) in the AlSPC-PDT group, 0.35 +/- 0.12 cm (0.20 - 0.55 cm) in the PI-PDT group, and 0.36 +/- 0.11 cm (0.20 - 0.50 cm) in the PSD-007-PDT group. These differences may be due to the differences of the dyes' light absorbance spectra. AlSPC's main absorbance peak is at 675 nm and HPD's is around 400 nm with a smaller peak at 630 nm. The penetration of 675 nm light through biologic tissue is deeper than that of 400 nm light and 630 nm light.

Citation Download Citation

Hong-Yu Yu, Rong-Chun Dong, Ji-Yao Chen, and Huai-Xin Cai "Depth of necrosis induced by photodynamic therapy with sulfonated aluminum phthalocyanine in S₁₈₀ fibrosarcoma of mice", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137033

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