Photodynamic effect of copper-vapor pumped-dye laser, He-Ne laser, and noncoherent red light to the liver in normal mice

Chuannong Zhou; Xuyan Song; Jinsheng Deng; Junlin Liang; Hua Zhang; Wenjia Huang; Tao Liu; Xian-wen Ha

doi:10.1117/12.137015

5 March 1993 Photodynamic effect of copper-vapor pumped-dye laser, He-Ne laser, and noncoherent red light to the liver in normal mice

Chuannong Zhou, Xuyan Song, Jinsheng Deng, Junlin Liang, Hua Zhang, Wenjia Huang, Tao Liu, Xian-wen Ha

Author Affiliations +

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137015
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

A quantitative comparison of the photodynamic effect of pulsed (copper vapor-pumped dye laser), continuous-wave laser (He-Ne laser), and non-coherent red light (filtered from a halogen lamp) to the liver in normal mice has been carried out. The mice (each group containing 18 - 20 mice) received hematoporphyrin derivative in a dose of 10 mg/kg iv 24 hours prior to light irradiation. The mouse livers were directly irradiated with different red light in a dose of 5, 10, 25, 50, or 100 J/cm², respectively. Forty-eight hours later the mice were killed, and the depth of liver necrosis was measured using a computer image-analysis system. No necrosis was found in the control liver irradiated with 500 J/cm² alone. The depth of photodynamic necrosis showed a light dose-dependent response. The mean depth of necrosis of all groups were compared statistically. The Cu-dye laser showed the best effect while the non-coherent light showed the poorest. There were significant differences between non-coherent light and laser irradiated groups, but not between Cu-dye and He-Ne laser groups. The results indicate that among the examined light sources, the Cu-dye laser is most suitable to photodynamic therapy (PDT) of tumors. However, the halogen lamp with a special filter device may still be occasionally used as a light source in PDT if needed.

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Chuannong Zhou, Xuyan Song, Jinsheng Deng, Junlin Liang, Hua Zhang, Wenjia Huang, Tao Liu, and Xian-wen Ha "Photodynamic effect of copper-vapor pumped-dye laser, He-Ne laser, and noncoherent red light to the liver in normal mice", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137015

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KEYWORDS

Lamps

Dye lasers

Liver

Copper

Photodynamic therapy

Helium neon lasers

Neon

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