Photodynamic effects of Can-Sha photosensitizer on transplanted tumors in mice

Jixiu Zhong; Lingling Zhu; Weijia Li; Yonghua Yang

doi:10.1117/12.137023

5 March 1993 Photodynamic effects of Can-Sha photosensitizer on transplanted tumors in mice

Jixiu Zhong, Lingling Zhu, Weijia Li, Yonghua Yang

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137023
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Can-sha photosensitizer (CPS) extracted from the silkworm excreta (a Chinese herb) was administered to tumor bearing mice by iv or the intragastrointestinal route in dosages of 50 mg/kg and 550 mg/kg, respectively. Six to ten hours later the tumorous site was irradiated with light. The results showed that the tumor inhibition rates were 69 - 98% by iv and 62 - 79% by intraduodenal (id) injection, but no photodynamic effect was found in the tumors of mice after administering CPD by p.o. ³H-TdR or ³-uR incorporation ability of the tumor cells pretreated with the drug and light was significantly inhibited.

Citation Download Citation

Jixiu Zhong, Lingling Zhu, Weijia Li, and Yonghua Yang "Photodynamic effects of Can-Sha photosensitizer on transplanted tumors in mice", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137023

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