Photodynamic therapy of recurrent cerebral glioma

Shu-Gan Zhu; Si-En Wu M.D.; Zong-Qian Chen; Wei Sun

doi:10.1117/12.137001

5 March 1993 Photodynamic therapy of recurrent cerebral glioma

Shu-Gan Zhu, Si-En Wu M.D., Zong-Qian Chen, Wei Sun

Proceedings Volume 1616, International Conference on Photodynamic Therapy and Laser Medicine; (1993) https://doi.org/10.1117/12.137001
Event: International Conference on Photodynamic Therapy and Laser Medicine, 1991, Beijing, China

Abstract

Photodynamic therapy (PDT) was performed on 11 cases of recurrent cerebral glioma, including 3 cases of recurrent glioblastoma, 7 of recurrent anaplastic astrocytoma, and 1 recurrent ependymoma. Hematoporphyrin derivative (HPD) was administered intravenously at a dose of 4 - 7 mg/kg 5 - 24 hours before the operation. All patients underwent a craniotomy with a nearly radical excision of the tumor following which the tumor bed was irradiated with 630 nm laser light emitting either an argon pumped dye laser or frequency double YAG pumped dye laser for 30 to 80 minutes with a total dose of 50 J/cm² (n equals 1), 100 J/cm² (n equals 2), 200 J/cm² (n equals 7), and 300 J/cm² (n equals 1). The temperature was kept below 37 degree(s)C by irrigation. Two patients underwent postoperative radiotherapy. There was no evidence of increased cerebral edema, and no other toxicity by the therapy. All patients were discharged from the hospital within 15 days after surgery. We conclude that PDT using 4 - 7 mg/kg of HPD and 630 nm light with a dose of up to 300 J/cm² can be used as an adjuvant therapy with no additional complications. Adjuvant PDT in the treatment of recurrent glioma is better than simple surgery.

Citation Download Citation

Shu-Gan Zhu, Si-En Wu M.D., Zong-Qian Chen, and Wei Sun "Photodynamic therapy of recurrent cerebral glioma", Proc. SPIE 1616, International Conference on Photodynamic Therapy and Laser Medicine, (5 March 1993); https://doi.org/10.1117/12.137001

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