Transluminal angiomicroscopy of arterial thrombosis and thrombolysis

Takanobu Tomaru M.D.; Yasumi Uchida M.D.; Fumitaka Nakamura M.D.; Atsuko Miwa M.D.; Koichiro Yamada M.D.; Tsuneaki Sugimoto

doi:10.1117/12.137310

28 August 1992 Transluminal angiomicroscopy of arterial thrombosis and thrombolysis

Takanobu Tomaru M.D., Yasumi Uchida M.D., Fumitaka Nakamura M.D., Atsuko Miwa M.D., Koichiro Yamada M.D., Tsuneaki Sugimoto

Author Affiliations +

Proceedings Volume 1642, Diagnostic and Therapeutic Cardiovascular Interventions II; (1992) https://doi.org/10.1117/12.137310
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

To examine the process of microscopic changes during arterial thrombosis and thrombolysis a novel angiomicroscope (3 or 4 mm in diameter, magnification rate X 145) was introduced through a sheath into the right iliac artery of anesthetized dogs. A small portion of the luminal surface was mechanically damaged and processes of thrombogenesis were examined. Platelet aggregation on the damaged portion, fibrin thread growth on the exfoliated endothelium and naked subendothelial layers, trapping of red blood cells by fibrin networks, and gradual growth of mixed thrombi were observed. Following administration of prourokinase, or t-PA, dispersion of platelet aggregates and red blood cells, simulating sandstorm and gradual melting of fibrin, were also observed. The results indicate that detailed microscopic processes of thrombogenesis and thrombolysis can be observed percutaneously by angiomicroscopy.

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Takanobu Tomaru M.D., Yasumi Uchida M.D., Fumitaka Nakamura M.D., Atsuko Miwa M.D., Koichiro Yamada M.D., and Tsuneaki Sugimoto "Transluminal angiomicroscopy of arterial thrombosis and thrombolysis", Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); https://doi.org/10.1117/12.137310

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