Quantification of brain tissue through incorporation of partial volume effects

Howard Donald Gage; Peter Santago II; Wesley E. Snyder

doi:10.1117/12.59414

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1 June 1992 Quantification of brain tissue through incorporation of partial volume effects

Howard Donald Gage, Peter Santago II, Wesley E. Snyder

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Proceedings Volume 1652, Medical Imaging VI: Image Processing; (1992) https://doi.org/10.1117/12.59414
Event: Medical Imaging VI, 1992, Newport Beach, CA, United States

Abstract

This research addresses the problem of automatically quantifying the various types of brain tissue, CSF, white matter, and gray matter, using T1-weighted magnetic resonance images. The method employs a statistical model of the noise and partial volume effect and fits the derived probability density function to that of the data. Following this fit, the optimal decision points can be found for the materials and thus they can be quantified. Emphasis is placed on repeatable results for which a confidence in the solution might be measured. Results are presented assuming a single Gaussian noise source and a uniform distribution of partial volume pixels for both simulated and actual data. Thus far results have been mixed, with no clear advantage being shown in taking into account partial volume effects. Due to the fitting problem being ill-conditioned, it is not yet clear whether these results are due to problems with the model or the method of solution.

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Howard Donald Gage, Peter Santago II, and Wesley E. Snyder "Quantification of brain tissue through incorporation of partial volume effects", Proc. SPIE 1652, Medical Imaging VI: Image Processing, (1 June 1992); https://doi.org/10.1117/12.59414

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