On-line IR analyzer system to monitor cephamycin C loading on ion-exchange resin

Sheldon Shank; Warren Russ; Douglas Gravatt; Wesley Lee; Steven M. Donahue

doi:10.1117/12.137755

14 August 1992 On-line IR analyzer system to monitor cephamycin C loading on ion-exchange resin

Sheldon Shank, Warren Russ, Douglas Gravatt, Wesley Lee, Steven M. Donahue

Proceedings Volume 1681, Optically Based Methods for Process Analysis; (1992) https://doi.org/10.1117/12.137755
Event: SPIE's 1992 Symposium on Process Control and Monitoring, 1992, Somerset, NJ, United States

Abstract

An on-line infrared analyzer is being developed for monitoring cephamycin C loading on ion exchange resin. Accurate measurement of product loading offers productivity improvements with direct savings from product loss avoidance, minimized raw material cost, and reduced off-line laboratory testing. Ultrafiltered fermentation broth is fed onto ion exchange columns under conditions which adsorb the product, cephamycin C, to the resin while allowing impurities to pass unretained. Product loading is stopped when the on-line analyzer determines that resin capacity for adsorbing product is nearly exhausted. Infrared spectroscopy has been shown capable of quantifying cephamycin C in the process matrix at concentrations that support process control decisions. Process-to-analyzer interface challenges have been resolved, including sample conditioning requirements. Analyzer requirements have been defined. The sample conditioning station is under design.

Citation Download Citation

Sheldon Shank, Warren Russ, Douglas Gravatt, Wesley Lee, and Steven M. Donahue "On-line IR analyzer system to monitor cephamycin C loading on ion-exchange resin", Proc. SPIE 1681, Optically Based Methods for Process Analysis, (14 August 1992); https://doi.org/10.1117/12.137755

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