Exogenous chromophores in Nd:YAG laser selective ablation of the model tissue

Vladimir Vinduska

doi:10.1117/12.146586

23 June 1993 Exogenous chromophores in Nd:YAG laser selective ablation of the model tissue

Vladimir Vinduska

Proceedings Volume 1878, Diagnostic and Therapeutic Cardiovascular Interventions III; (1993) https://doi.org/10.1117/12.146586
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Exogenous chromophores have the capability to enhance atheromatous plaque ablation during laser angioplasty. A number of dyes have been tested for their effect on the tissue absorption for lasers emitting at different wavelengths, but little is known about conditions governing this selectivity. 1064 nm and 1300 nm light transmission and scattering of 0.6 mm thick samples of agar with different concentrations of talc and black ink were compared to those of atheromatous tissue of the same thickness in order to determine the sample with most similar optical properties. We measured ablation threshold in air for both wavelengths, temperatures in adjacent agar in air for both wavelengths, ablation thresholds in water for 1064 nm, temperatures in the adjacent agar in the water for 1064 nm, ablation threshold in the air for 1064 nm and 5, 10, and 15 mm fiber tip distances. Selectivity of the laser ablation is achievable by saturation of the tissue with chromophore dyes. Higher absorption results in lower thermal damage of non-ablated tissue, especially in water. Selectivity in water is more pronounced than that in air. Selectivity was not influenced by the size of the laser spot in the investigated range.

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Vladimir Vinduska "Exogenous chromophores in Nd:YAG laser selective ablation of the model tissue", Proc. SPIE 1878, Diagnostic and Therapeutic Cardiovascular Interventions III, (23 June 1993); https://doi.org/10.1117/12.146586

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