Fluorescence-based tissue biopsy needle: in vivo optical diagnosis in rat model with low cost, arc-lamp-based system

Karlheinz Strobl; Sandor G. Vari M.D.; Theodore G. Papazoglou; Warren S. Grundfest M.D.; Doug M. Brenner

doi:10.1117/12.147494

7 July 1993 Fluorescence-based tissue biopsy needle: in vivo optical diagnosis in rat model with low cost, arc-lamp-based system

Karlheinz Strobl, Sandor G. Vari M.D., Theodore G. Papazoglou, Warren S. Grundfest M.D., Doug M. Brenner

Author Affiliations +

Proceedings Volume 1892, Medical Lasers and Systems II; (1993) https://doi.org/10.1117/12.147494
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

The diagnostic capability of an optical biopsy probe combined with a tumor selective fluorescence drug (Photofrin II^R) was tested in an in vivo animal model. The optical biopsy system is comprised of an arc lamp, an optical contact probe, and low cost detectors. We illuminated tissue with blue (405 nm) light and detected the diffusely reflected excitation light, the tissue autofluorescence (500 - 540 nm), and the drug fluorescence near 630 nm. By using the appropriate signal ratios, normal, inflamed and malignant lymph nodes could be distinguished with a high specificity and sensitivity (85 - 95%).

Citation Download Citation

Karlheinz Strobl, Sandor G. Vari M.D., Theodore G. Papazoglou, Warren S. Grundfest M.D., and Doug M. Brenner "Fluorescence-based tissue biopsy needle: in vivo optical diagnosis in rat model with low cost, arc-lamp-based system", Proc. SPIE 1892, Medical Lasers and Systems II, (7 July 1993); https://doi.org/10.1117/12.147494

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