Computer aided morphometry of the neonatal fetal alcohol syndrome face

Lawrence Chik; Robert J. Sokol; Susan S. Martier

doi:10.1117/12.154521

14 September 1993 Computer aided morphometry of the neonatal fetal alcohol syndrome face

Lawrence Chik, Robert J. Sokol, Susan S. Martier

Proceedings Volume 1898, Medical Imaging 1993: Image Processing; (1993) https://doi.org/10.1117/12.154521
Event: Medical Imaging 1993, 1993, Newport Beach, CA, United States

Abstract

Facial dysmorphology related to Fetal Alcohol Syndrome (FAS) has been studied from neonatal snapshots with computer-aided imaging tools by looking at facial landmarks and silhouettes. Statistical methods were used to characterize FAS-related midfacial hypoplasia by using standardized landmark coordinates of frontal and profile snapshots. Additional analyses were performed by tracing a segment of the facial silhouettes from the profile snapshots. In spite of inherent distortions due to the coordinate standardization procedure, controlled for race, three significant facial landmark coordinates accounted for 30.6% of the explained variance of FAS. Residualized for race, eight points along the silhouettes were shown to be significant in explaining 45.8% of the outcome variance. Combining the landmark coordinates and silhouettes points, 57% of the outcome variance was explained. Finally, including birthweight with landmark coordinates and silhouettes, 63% of the outcome variance was explained, with a jackknifed sensitivity of 95% (19/20) and a specificity of 92.9% (52/56).

Citation Download Citation

Lawrence Chik, Robert J. Sokol, and Susan S. Martier "Computer aided morphometry of the neonatal fetal alcohol syndrome face", Proc. SPIE 1898, Medical Imaging 1993: Image Processing, (14 September 1993); https://doi.org/10.1117/12.154521

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