Bactericidal effect of YAG laser irradiation sensitized by chlorin e6

Andrei Fomichev; I. Krylov; A. Degtyareva; Vladimir P. Zorin; Victor P. Mikhailov; I. Manichev; S. N. Charankevich

doi:10.1117/12.146199

17 June 1993 Bactericidal effect of YAG laser irradiation sensitized by chlorin e6

Andrei Fomichev, I. Krylov, A. Degtyareva, Vladimir P. Zorin, Victor P. Mikhailov, I. Manichev, S. N. Charankevich

Proceedings Volume 1922, Laser Study of Macroscopic Biosystems; (1993) https://doi.org/10.1117/12.146199
Event: Laser Spectroscopy of Biomolecules: 4th International Conference on Laser Applications in Life Sciences, 1992, Jyvaskyla, Finland

Abstract

The photoinduced damage sensitized by chlorin e₆ to obligate-pathogenic bacteria Klebsiella rhinoscleromatis in the presence of streptomycin has been studied. A significant synergic effect is observed resulting in both higher photoinactivation rates in the presence of streptomycin and reduction of the threshold of toxic antibiotic concentrations for bacteria, exposed to the sublethal photosensitized action. One may expect that the use of the combined action of a photosensitizer and visible light will allow one to decrease an effective antibiotic dose using combined photo- and chemotherapy of scleroma.

Citation Download Citation

Andrei Fomichev, I. Krylov, A. Degtyareva, Vladimir P. Zorin, Victor P. Mikhailov, I. Manichev, and S. N. Charankevich "Bactericidal effect of YAG laser irradiation sensitized by chlorin e6", Proc. SPIE 1922, Laser Study of Macroscopic Biosystems, (17 June 1993); https://doi.org/10.1117/12.146199

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